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January 1971

Polyarteritis Nodosa in Two Siblings

Author Affiliations

From the departments of pathology (Drs. Harrer and Baylis) and pediatrics (Drs. Leff, Jackson, and Faber), Thomas Jefferson University Hospital, Philadelphia.

Am J Dis Child. 1971;121(1):67-70. doi:10.1001/archpedi.1971.02100120103017

The identical presentation of signs, symptoms, and fatal prognosis of polyarteritis nodosa in two male siblings shows a familial history of a collagen disorder (systemic lupus erythematosus [SLE] ) and multiple allergies. These occurrences in this family lend support to the concept that so-called autoimmune diseases may be genetically determined. To our knowledge, the simultaneous occurrence of polyarteritis in siblings has not been previously reported. This fact, plus the family history of multiple allergens and SLE, is the purpose of this case report.