Three patients appear to represent a new syndrome of unknown etiology, manifested by abnormally long but sparse eyelashes and brows (congenital trichomegaly), noninflammatory pigmentary degeneration of the retina, and sustained growth retardation originating in utero. The syndrome does not appear to be associated with a recognizable chromosomal defect nor with a familial pattern of inheritance. Further clarification of the genetics of this disorder and of the basis for the mental retardation will require study of additional cases.
Corby DG, Lowe RS, Haskins MRC, Hebertson CLM. Trichomegaly, Pigmentary Degeneration of the Retina, and Growth RetardationA New Syndrome Originating in Utero. Am J Dis Child. 1971;121(4):344–345. doi:10.1001/archpedi.1971.02100150118018
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