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July 1971

Coexistence of Hodgkin's Disease and Down's Syndrome

Am J Dis Child. 1971;122(1):71-73. doi:10.1001/archpedi.1971.02110010107021

A child with Down's syndrome developed Hodgkin's sarcoma. Chromosomal analysis of an involved node demonstrated that the trisomy was of the 21-22 group, and the lymph node cells contained a number of chromosomal breaks and fragments. This case is another example of the association between Down's syndrome and the development of lymphoreticular malignancies.