We reviewed 100 cases of appendicitis with perforation during infancy and childhood, including symptoms, physical signs, delay in diagnosis, and preoperative preparation. The complications following appendicitis with perforation included wound abscess, pelvic abscess, intraperitoneal abscess, intestinal obstruction, fecal fistula, rectal bleeding, gram negative sepsis, and acute orchitis. A case report of a child with multiple complications is presented. Early diagnosis and operation, before perforation takes place, is the only means of prevention, and every physician caring for children should bear this admonition in mind, especially when examining the child with fever, abdominal pain, and vomiting.