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October 1971

Congenital Myasthenia Gravis: A Case Report With Thymectomy and Electron Microscopic Study of Resected Thymus

Author Affiliations

Los Angeles
From the departments of pediatrics (Dr. Clarke) and anatomy (Dr. Van de Velde), University of Southern California School of Medicine; Department of Pediatrics, Childrens Hospital of Los Angeles (Dr. Clarke); and Division of Laboratories, Cedars-Sinai Medical Research Center, (Dr. Van de Velde), Los Angeles.

Am J Dis Child. 1971;122(4):356-361. doi:10.1001/archpedi.1971.02110040140017

Thymectomy and subsequent short course of corticotropin in high doses did not change the course of persistent and unusually severe congenital myasthenia gravis in a 5-year-old boy. Grossly, the thymus appeared normal in size and consistency for the patient's age. On histopathologic examination several changes consistent with an autoimmune disorder were demonstrable, including lymphoid hyperplasia and large numbers of thymic plasma cells. Electron microscopic studies showed intralobular vascular changes and the presence of thymic myoid cells. Their possible significance is discussed.

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