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January 1972

Epidemiological Implications of Rubella "Vaccine Failures"

Author Affiliations

Los Angeles
From the Hastings Foundation Infectious Disease Laboratory and the Departments of Pediatrics (Drs. Wilkins and Portnoy and Miss Salvatore), medicine (Dr. Leedom), community medicine, and public health (Dr. Portnoy and Miss Salvatore), University of Southern California, Los Angeles; and the Pacific State Hospital, Pomona, Calif.

Am J Dis Child. 1972;123(1):31-33. doi:10.1001/archpedi.1972.02110070081009

The responses of two rubella virus vaccine, live attenuated HPV-80 "vaccine failures" to intranasal challenge with low passage Brown stain of rubella virus were studied. Results indicated that "vaccine failures" shed live rubella virus from their pharynges for an extended period. These data are in contrast to those reported concerning reinfected vaccine-immunes. Further, following challenge, "vaccine failures" do not exhibit the signs and symptoms of clinical rubella. "Vaccine failures" may play a role in the transmission of this disease.

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