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January 1972

Tuberous Sclerosis: Clinical, Endocrine, and Metabolic Studies

Author Affiliations

From the State of Washington Department of Social and Health Services, Rainier School, Buckley, Wash (Drs. Sareen and Ruvalcaba) and the Division of Endocrinology and Metabolism, Department of Pediatrics, University of Washington, Seattle (Drs. Sareen, Ruvalcaba, Scotvold, Mahoney and Kelley).

Am J Dis Child. 1972;123(1):34-39. doi:10.1001/archpedi.1972.02110070084010

Clinical, endocrine, and metabolic evaluations were performed in seven institutionalized patients with tuberous sclerosis. Several of these patients had evidence of abnormal pituitary adrenal function; two had thyroid disorders; five had abnormal responses to intravenous glucose tolerance tests; and all seven patients had high serum alkaline phosphatase levels. Skeletal surveys disclosed multiple skeletal defects including abnormalities in the size of the sella turcica. These findings indicate that endocrine and metabolic dysfunction is a frequent component of tuberous sclerosis and may be evidenced by a variety of manifestations.

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