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January 1972

Echovirus 14 Infection Associated With Fatal Neonatal Hepatic Necrosis

Author Affiliations

Hanover, NH; Boston; Hanover, NH
From the Section of Pediatrics, Hitchcock Clinic (Dr. Hughes), and the departments of medicine and pathology (Drs. Hughes, Benirschke, and de Hoyos-Guevara), Dartmouth Medical School, Hanover, NH; the Research Division of Infectious Diseases, Department of Medicine, Childrens Hospital Medical Center (Dr. Wilfert and Miss Moore), Boston. Dr. Wilfert is now with Duke University School of Medicine, Durham, NC. Dr. Benirschke, is now with the University of California School of Medicine, San Diego and La Jolla, Calif.

Am J Dis Child. 1972;123(1):61-67. doi:10.1001/archpedi.1972.02110070111017

Echovirus 14 was isolated from the liver of a newborn infant with fatal hepatic necrosis. It appeared likely that the infection was acquired in utero. Ultrastructurally, the findings in the liver cells were consistent with a viral infection. In cell cultures the viral isolate was found to produce crystalline inclusions in the nucleus and cytoplasm. Negative stained virions measured approximately 30.3 mμ in diameter. To our knowledge, the electron microscopy of echovirus 14 has not been previously reported.