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March 1972

Mite Sensitivity in House Dust-Allergic Children: Evaluation by Clinical and Laboratory Methods

Author Affiliations

Columbus, Ohio; San Francisco
From the Departments of Pediatrics, University of California-San Francisco (Dr. Frick) and Ohio State University, Columbus, Ohio (Dr. Bullock).

Am J Dis Child. 1972;123(3):222-226. doi:10.1001/archpedi.1972.02110090092010

House dust and mite sensitivity were evaluated in 24 house dust-allergic children by comparing clinical history, scratch testing, skin window eosinophilia, and leukocyte histamine release. Allergy to mites was found in almost all house dust-allergic children. Mite extracts were 100 to 1,000 times as allergenic as house dust extracts on a weight basis. The three tests were usually all positive. In vivo skin window eosinophilia may be useful in ruling out false-positive skin tests. In vitro leukocyte histamine release is useful in quantitating house dust allergic sensitivity. Skin testing still remains a reliable method of screening for house dust and mite sensitivity as causes of asthma in children.