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March 1972

Fronto-metaphyseal Dysplasia: A Progressive Disease of Bone and Connective Tissue

Author Affiliations

From Royal Children's Hospital (Drs. Danks, Mayne, Hall, and McKinnon) and the University of Melbourne (Dr. Danks).

Am J Dis Child. 1972;123(3):254-258. doi:10.1001/archpedi.1972.02110090124022

In a patient with fronto-metaphyseal dysplasia, progressive joint deformities and osteolytic changes in the carpal bones observed suggest that this condition is a "heritable disorder of connective tissue." Metachromatic granules were demonstrated in cultured fibroblastic cells.

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