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April 1972

Etiologic Factors in Neonatal Hepatitis: A Preliminary Report of a Regional Survey

Author Affiliations

From the Department of Child Health and the Liver Unit, King's College Hospital, London.

Am J Dis Child. 1972;123(4):300-301. doi:10.1001/archpedi.1972.02110100032011

All cases of neonatal hepatitis, as. determined by clinical features, results of liver function tests, and histologic examination, appearing in a circumscribed area of Southeast England served by King's College Hospital, have been investigated to determine possible etiological factors. The patients and their families have been studied for evidence of viral in

fection, toxoplasmosis, Australia antigen (measured by immunodiffusion and immunoelectrophoresis) and the epidemic hepatitis associated antigen (EHAA) Milan antigen, described by Del Prete and colleagues.1 Concentrations of α1-antitrypsin were measured by starch gel electrophoresis at pH 52 in considering possible genetic factors.

Fifteen patients have been studied to date (Table). Eight patients have made a complete clinical and biochemical recovery. One case has progressed to cirrhosis and the remainder continue to show evidence of active liver disease. One infant was found to have the trisomy 18 syndrome and another to have generalized infection with