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April 1972

Relationship of Milan Antigen to Abnormal Serum Lipoprotein

Author Affiliations

From Department of Microbiology, London School of Hygiene and Tropical Medicine (Drs. Taylor and Zuckerman); Department of Virology Royal Postgraduate Medical School (Dr. Almeida); London; and Pfizer Ltd, Sandwich, Kent, England (J.M. Leach).

Am J Dis Child. 1972;123(4):329-331. doi:10.1001/archpedi.1972.02110100061025

In 1970 Del Prete et al1 described the detection by immunodiffusion in gel of a new antigen in the sera of patients with epidemic hepatitis by using an antiserum obtained in Milan from a multiple-transfused patient with aplastic anemia. A high proportion of 127 sera obtained from three different epidemics of short-incubation hepatitis, which were consistently negative when tested against antiserum to Australia antigen, reacted with the Milan antibody. Of the sera collected during the first two weeks of illness 90% gave positive precipitin lines. The antigen, which was named epidemic hepatitis-associated antigen, was cleared from the serum with clinical improvement. It was not detected in 2,000 control serum samples collected from routinely vaccinated persons in Milan, nor in the serum of 50 patients with other viral diseases. The exact nature of the antigen has remained obscure since it was first described. We have attempted to establish some of