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May 1972

Streptococcal Pharyngitis Therapy: Comparison of Cephalexin, Phenoxymethyl Penicillin, and Ampicillin

Author Affiliations

New Hyde Park, NY; Atlanta
From the departments of pediatrics and laboratories, Long Island Jewish Medical Center, New Hyde Park, NY (Drs. Stillerman and Isenberg); and the Streptococcus Bacteriology Unit, Center for Disease Control, Atlanta (Dr. Moody). Dr. Moody is now with Wellcome Reagents Division, Burroughs Wellcome Co., Research Triangle Park, NC.

Am J Dis Child. 1972;123(5):457-461. doi:10.1001/archpedi.1972.02110110085005

Results of cephalexin monohydrate and potassium phenoxymethyl penicillin were compared in children with pharyngitis and group A streptococci in two consecutive studies, 1968 to 1969 and 1969 to 1970. Ampicillin anhydrous was included in the first study. The patients were assigned randomly to one of the antibiotics, 0.5 gm daily for ten days. Recurrences, detected by routine weekly cultures, of the original group A streptococcal types within three weeks after end of treatment were classified as failures. The failure rates in the first study were 11% (4/38) for cephalexin, 26% (10/39) for phenoxymethyl penicillin, and 27% (10/27) for ampicillin. The failure rates in the second study were 9% (4/46) for cephalexin and 20% (10/50) for potassium phenoxymethyl penicillin. In the combined studies cephalexin was more effective than potassium phenoxymethyl penicillin (P <.05).

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