The management of five asthmatic children with respiratory failure who received controlled ventilation was facilitated by administration of morphine sulfate. Indications for the use of morphine sulfate and controlled ventilation included a depressed level of consciousness, diminished response to stimuli, agitation, increasing hypoxemia, and hypercapnea. Volume-regulated ventilators appeared to be more effective than pressure-limited respirators in these cases.
Soleymani Y, Weiss NS, Sinnott EC, Goldzier S. Management of Life-Threatening Asthma in Children: A Preliminary Study of the Use of Morphine in Respiratory Failure. Am J Dis Child. 1972;123(6):533–540. doi:10.1001/archpedi.1972.02110120057002
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