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June 1972

X-Linked Thrombocytopenic Purpura: I. Clinical and Genetic Studies of a Kindred

Author Affiliations

Gainesville, Fla
From the Division of Pediatric Hematology, Department of Pediatrics, University of Florida College of Medicine, Gainesville. Dr. Chiaro is now with Charlotte (NC) Memorial Hospital.

Am J Dis Child. 1972;123(6):565-568. doi:10.1001/archpedi.1972.02110120089008

Thirteen members of a family of 182 demonstrated laboratory or historical evidence of thrombocytopenia. The onset of bleeding symptoms occurred around the age of 6 years, followed by spontaneous remission of symptoms but not thrombocytopenia in early adult life. Treatment ranged from symptomatic care to long-term steroid therapy or splenectomy. The disorder is inherited in an X-linked recessive manner but appears to be distinct from the Wiskott-Aldrich syndrome in other respects.

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