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July 1972

Cytomegalovirus Infections of Man.

Author Affiliations

Los Angeles

Am J Dis Child. 1972;124(1):146-147. doi:10.1001/archpedi.1972.02110130148025

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This little book has been a pleasure to read. It is truly a complete review of the subject, including a historical summary, basic virological information for investigators, and a thorough discussion of epidemiology, pathogenesis, and the many clinical aspects of this viral infection. Congenital and acquired forms of cytomegalovirus inclusion disease (CID) are discussed fully at all ages, especially in infants, after birth, who are commonly infected with inapparent disease. The problem of congenital or acquired infection, its common occurrence following surgery and blood transfusions, especially open-heart surgery with extracorporeal circulation is presented.

A thorough discussion of cytomegalovirus mononucleosis, occurring in patients without heterophile antibodies is very interesting. The book is full of surprises such as the development of CID in kidney transplant patients in which the donor was determined to be immunologically and virologically negative. The pathogenic role of immunosuppressive drugs is reviewed.

Documentation of various strains and serotypes,

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