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August 1972

Mental Retardation, Abnormal Fingers, and Skeletal Anomalies: Coffin's Syndrome

Author Affiliations

North Ryde, NSW Australia
Prom Oliver Latham Laboratory, Psychiatric Centre, North Ryde, NSW Australia. Dr. Procopis is now with the University of Kentucky Medical Center, Lexington.

Am J Dis Child. 1972;124(2):258-261. doi:10.1001/archpedi.1972.02110140108016

A family with four severely mentally retarded male members who have odd facial features, broad tapering fingers, and abnormal skeletal development is described. Some female members of the kindred show a milder degree of mental retardation and less marked somatic features. Inheritance appears to be via a dominant trait with the possibility of X-linkage being present. No metabolic abnormality has been demonstrated.