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November 1972

45, X Chromosome Abnormality in the Offspring of a Narcotic Addict

Author Affiliations

Newark, NJ
From the departments of pediatrics (Dr. Kushnick) and preventive medicine (Ms. Robinson and Ms. Tsao), division of drug abuse, New Jersey Medical School, Newark.

Am J Dis Child. 1972;124(5):772-773. doi:10.1001/archpedi.1972.02110170150026

During a cytogenetic investigation of adult narcotic addicts and their newborn offspring, a female infant with a 45,X karyotype was born to a woman who used heroin and cocaine. The baby had multiple features consistent with the Turner's syndrome phenotype, with the additional findings of bilaterally absent fifth toes. This infant was one of 30 offspring of drug addicts, and while this case might represent a fortuitous circumstance, the possibility of increased incidence of newborn chromosomal aberration with parental drug addiction must be considered.