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December 1972

Candida albicans Meningitis Successfully Treated With Amphotericin B

Author Affiliations

Columbus, Ohio
From the departments of pediatrics and medical microbiology, Ohio State University College of Medicine, and the Children's Hospital Research Foundation, Columbus, Ohio.

Am J Dis Child. 1972;124(6):926-929. doi:10.1001/archpedi.1972.02110180128020

This patient was treated for pneumonia at 13 months, at which time she was found to be anemic. She remained severely anemic at 15 months when she was admitted to a hospital where a diagnosis of aseptic meningitis was made without an initial lumbar puncture. During the month of hospitalization she received multiple antibiotics, blood transfusions, and steroids. Multiple ulcers of the lower extremities developed at the sites of indwelling venous catheters, concomitant with oral moniliasis. When she was admitted to Children's Hospital Candida albicans was isolated from these ulcers and from cerebrospinal fluid on two separate occasions. Treatment with amphotericin B was well tolerated except for transient azotemia and hyperpyrexia. Reevaluation 18 months after her illness failed to reveal evidence of sequelae attributable either to her disease or treatment.