A 161/2-year-old white girl with clinical features resembling Senior syndrome (short stature with antenatal onset, onychodysplasia, and digital anomalies) is described. During puberty she manifested a nine-year advancement in osseous maturation over a five-year period without a concomitant increase in growth rate. There has been no evidence of excess androgen or estrogen production, and she has received no exogenous hormones. Whether this phenomenon is a common or sporadic feature of this syndrome is unknown, but caution must be used in counseling these subjects as to eventual height expectation.
Mace JW, Linda L, Gotlin RW. Short Stature and Onychodysplasia: Report of a Case Resembling Senior Syndrome. Am J Dis Child. 1973;125(1):114–116. doi:https://doi.org/10.1001/archpedi.1973.04160010078019
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