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January 1973

Short Stature and Onychodysplasia: Report of a Case Resembling Senior Syndrome

Author Affiliations

Calif; Denver
From the Loma Linda (Calif) University School of Medicine (Dr. Mace) and the University of Colorado School of Medicine, Denver (Dr. Gotlin).

Am J Dis Child. 1973;125(1):114-116. doi:10.1001/archpedi.1973.04160010078019

A 161/2-year-old white girl with clinical features resembling Senior syndrome (short stature with antenatal onset, onychodysplasia, and digital anomalies) is described. During puberty she manifested a nine-year advancement in osseous maturation over a five-year period without a concomitant increase in growth rate. There has been no evidence of excess androgen or estrogen production, and she has received no exogenous hormones. Whether this phenomenon is a common or sporadic feature of this syndrome is unknown, but caution must be used in counseling these subjects as to eventual height expectation.

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