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April 1973

Intermittent Arthritis Following Rubella Vaccination: A Three-Year Follow-Up

Author Affiliations

Eloise, MI; Detroit
From the Department of Internal Medicine, University of Michigan, Ann Arbor, and Wayne County General Hospital, Eloise, MI (Drs. Thompson and Weiss) and Parke, Davis & Company, Detroit (Drs. Shillis and Brackett).

Am J Dis Child. 1973;125(4):526-530. doi:10.1001/archpedi.1973.04160040040008

Thirty-nine of 40 children who developed arthritis following vaccination with HPV-77-DK 12 rubella vaccine were followed up three years after vaccination. Definite recurrent attacks of arthritis occurred in 11 children (28%) and possible recurrences in 7 (18%). The knee was the joint most commonly involved (78%). Duration of each attack was from one to five days with complete clearing between attacks. With time, the intervals between attacks increased and in most children the attacks appear to have stopped.

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