During the 30-month period between May 1969, and October 1971, 6,991 live infants were delivered at George Washington University Hospital. Seventy-nine infants (1.1%) developed idiopathic respiratory distress syndrome (IRDS). Twenty-six infants were judged to have ventilatory failure requiring assisted ventilation. Continuous negative-pressure ventilation (CNPV) was instituted for varying periods in these infants. Among the 26 infants with respiratory failure who were treated by this method, 19 (73%) survived and 7 (27%) died. Of teh total 79 infants with IRDS, 66 (84%) survived and 13 (16%) died.
Complications encountered during mechanical ventilation of the infants are discussed as well as advantages and disadvantages of the procedure. The overall experience with mechanically assisted ventilation, using CNPV in infants with respiratory failure due to IRDS, suggests that improved survival rates can be obtained without significant complications.
Ballard RA, Kraybill EN, Hernandez J, Renfield ML, Blankenship WJ. Idiopathic Respiratory Distress Syndrome: Treatment With Continuous Negative-Pressure Ventilation. Am J Dis Child. 1973;125(5):676–681. doi:https://doi.org/10.1001/archpedi.1973.04160050030006
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