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May 1973

Hyperglycemic Nonketotic Coma in a Postpancreatectomy Diabetic Infant

Author Affiliations

Louisville, Ky
From the Section of Endocrinology, Department of Pediatrics (Drs. Kim and MacMillan), and Section of Pediatric Surgery, Department of Surgery (Dr. Johnson), University of Louisville (Ky) School of Medicine.

Am J Dis Child. 1973;125(5):755-756. doi:10.1001/archpedi.1973.04160050093020

Recurrent and ultimately fatal nonketotic hyperglycemic coma occurred in an 11-month-old boy who previously had undergone pancreatectomy for intractable hypoglycemia. The association of this phenomenon with postpancreatectomy diabetes mellitus has not been previously reported but may be comparable to observed occurrences in pancreatitis and carcinoma of the pancreas. Although glucocorticoids and diphenylhydantoin sodium were administered to this infant, and both have been reported as possible causes of nonketotic hyperglycemic coma, it is difficult to incriminate either agent in this case.