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June 1973

Coffin-Siris Syndrome: Two New Cases

Author Affiliations

From the Dysmorphology Unit, Department of Pediatrics, University of Washington School of Medicine, Seattle.

Am J Dis Child. 1973;125(6):838-840. doi:10.1001/archpedi.1973.04160060048010

Two additional cases of a recently delineated pattern of malformation, the Coffin-Siris syndrome, bring the number of reported cases to six. The features of the disorder variably include growth and mental deficiency; a coarse appearing facies with low nasal bridge, wide nose and/or mouth, and thick lips; hypoplastic nails, especially those of the fifth finger and toes; hirsutism and sparse scalp hair; and lax joints and/or hypotonia. These patients tend to have feeding problems in infancy and frequent respiratory infections. The disorder has been a sporadic one in each family. No chromosomal abnormality has been detected, and the cause remains undetermined.

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