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July 1973

Penicillin Phenoxymethyl: Use in Rheumatic Fever Prophylaxis

Author Affiliations

From the Division of Infectious Disease, Department of Medicine (Dr. Phair and Ms. Carleton), and the Department of Pediatrics (Dr. Weihl), University of Cincinnati Medical Center.

Am J Dis Child. 1973;126(1):48-50. doi:10.1001/archpedi.1973.02110190044008

The oral use of penicillin phenoxymethyl in a rheumatic fever prophylaxis program was investigated. The frequency of recurrences of rheumatic fever were low overall (1.6/100 patient years). Among children who complied with the program, as determined by assay of urine for penicillin activity, no recurrences were noted. Approximately three fifths of the children receiving penicillin carried penicillin resistant α-hemolytic streptococci in the oropharynx; resistant organisms were recovered from 22% of control children. The resistant streptococci remained sensitive to erythromycin, lincomycin, and the cephalosporin antibiotics.

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