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July 1973

Multiple Congenital Defects Associated With 45,XO/46,XYq- Mosaicism

Author Affiliations

From the departments of pathology and pediatrics and the Research Institute, the Hospital for Sick Children, and the departments of pathology and pediatrics, the University of Toronto, Toronto. Dr. Surana is now with the Howard University College of Medicine and Freedmen's Hospital, Washington, DC.

Am J Dis Child. 1973;126(1):75-77. doi:10.1001/archpedi.1973.02110190063013

Chromosome studies were made on a 2-month-old boy with multiple congenital anomalies including an elongated large head, capillary hemangiomas, hypertelorism, bilateral cleft lip and cleft palate, overlapping fingers, and an undescended testis. Lymphocyte cultures revealed 46 chromosomes with a minute Y chromosome with deletion of most of the long arm; however, there was mosaicism in fibroblast cultures with a 45,XO/46,XYq- pattern. The parents' karyotypes were normal, and the Y chromosome of the father was of normal size with characteristic bright fluorescence pattern.

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