Clindamycin (7-chloro-7-deoxy lincomycin) is a semisynthetic antibiotic produced by the replacement of the 7-hydroxyl group by a halogen in the parent compound lincomycin. In clinical trials clindamycin has been found to be effective in eradicating thoracic, abdominal, and pelvic infections with bacteroides. This drug has not been tried in anaerobic central nervous system infections, however.
A 6-year-old girl developed urticaria following chloramphenicol administration for bacteroides brain abscess. Chloramphenicol was discontinued and in its place she was given clindamycin. She recovered completely after surgery and prolonged antibiotic therapy with clindamycin.
Khuri-Bulos N, McIntosh K, Ehret J. Bacteroides Brain Abscess Treated With Clindamycin. Am J Dis Child. 1973;126(1):96–98. doi:10.1001/archpedi.1973.02110190084018
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