A girl with congenital aortic stenosis underwent open commissurotomy. Postoperatively, she developed Enterobacter cloacae bacteremia followed by endocarditis. The combination of carbenicillin disodium and kanamycin sulfate was shown by in vitro tests to have a synergistic, bactericidal effect against this organism. The administration of these antibiotics resulted in cure of the endocarditis. Carbenicillin may be useful in the treatment of endocarditis due to gram-negative bacteria.
Lerer RJ. Postoperative Endocarditis Due to Enterobacter cloacae: Report of a Case Cured by Antibiotic Therapy. Am J Dis Child. 1973;126(3):352–353. doi:10.1001/archpedi.1973.02110190310013
Artificial Intelligence Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.