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September 1973

Urosepsis With Jaundice Due to Hemolytic Escherichia coli

Am J Dis Child. 1973;126(3):414. doi:10.1001/archpedi.1973.02110190356026

To the Editor.—At the Cook County Children's Hospital, urinary tract infection continues to be a significant etiological factor causing jaundice in early infancy.1 Our series now encompasses 22 bottle-fed infants who were discharged apparently normal from the nursery and returned with jaundice. There were 18 boys and 4 girls, with an age range of 8 to 56 days. The bilirubin value ranged from 6.0 to 48.2 mg/100 ml. In the two youngest infants, 8 and 9 days, there was little direct reacting bilirubin. The other infants had elevated levels of direct reacting bilirubin which accounted for 24% to 60% of the total bilirubin. The blood urea nitrogen value ranged from 18 to 153 mg/100 ml. Severe acidosis as judged by a low carbon dioxide combining power (<15) was present in 13 infants and another 6 were mildly acidotic. It would appear that this is not a clustering