A 10-year-old black girl with presumed rheumatoid arthritis and sickle thalassemia disease developed abnormalities of the prothrombin time and serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), and alkaline phosphatase values on three occasions following aspirin therapy. These abnormalities developed at salicylate levels as low as 18 mg/100 ml and persisted for more than 60 days following discontinuation of the aspirin therapy.
Athreya BH, Gorske AL, Myers AR. Aspirin-Induced Abnormalities of Liver Function. Am J Dis Child. 1973;126(5):638–641. doi:10.1001/archpedi.1973.02110190510010
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