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December 1973

Commercial Preparations of Prothrombin Complex: A Clinical Comparison

Author Affiliations

From the Department of Pediatrics, University of Illinois Medical Center, the Abraham Lincoln School of Medicine, Chicago.

Am J Dis Child. 1973;126(6):775-777. doi:10.1001/archpedi.1973.02110190625007

A comparative clinical study was performed of two commercial preparations of prothrombin complex concentrates, Proplex and Konyne. Five patients with severe factor IX—deficient hemophilia (Christmas disease) were given each of these products in two separate studies. Postinfusion recoveries of factors II, VII, IX, and X and survival characteristics of factor IX were compared. A significantly greater recovery of factor II was observed following the Konyne infusions. The postinfusion recovery levels and survival characteristics of factor IX were similar with the two preparations. These materials appear to be of equal effectiveness for the treatment of factor IX—deficient hemophilia when small or moderate doses are required. When large quantities are to be administered, specific risk factors may need to be taken into account for both preparations.

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