[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
December 1973

Propranolol in Imipramine Poisoning

Am J Dis Child. 1973;126(6):847-849. doi:10.1001/archpedi.1973.02110190689023

A 26-month-old girl ingested 250 mg of imipramine hydrochloride (Tofranil). She developed respiratory arrest, convulsions, coma, and four episodes of cardiac asystole and had eight episodes of ventricular fibrillation. Propranolol hydrochloride (Inderal) effectively converted the fibrillation to normal sinus rhythm after seven failures with the use of direct-current defibrillation. Continuous gastric lavage, mechanical ventilation, and symptomatic therapy contributed to a favorable outcome.