A family of three children exhibited the tricho-rhino-phalangeal (TRP) syndrome. The father showed the characteristic facial features and microscopic evidence of scanty and fine hair, but no roentgenographic evidence of abnormal phalanges. The mother, in turn, showed no clinical evidence of having the syndrome, but she did show roentgenographic evidence of phalangeal dysplasia.
It is postulated that this family shows the autosomal dominant type of the TRP syndrome with father-to-son transmission.
Pashayan HM, Solomon LM, Chan G. The Tricho–Rhino–Phalangeal Syndrome. Am J Dis Child. 1974;127(2):257–261. doi:10.1001/archpedi.1974.02110210107016
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