It is now recognized that aspirin alters platelet function, causing impairment of small vessel hemostasia and prolongation of bleeding time. Therefore, aspirin should be avoided in those who have a tendency to bleed. In this study, a standardized bleeding time, using the template method, has been used to screen a number of common analgesics and anti-inflammatory agents (propoxyphene hydrochloride, salicylate choline, pentazocine hydrochloride, prednisone, and codeine) in three patients with hemophilia A and ten normal volunteers. A comparison of the bleeding times, before and after ingestion of these drugs, showed no major differences. These agents are suggested for therapy in those patients with pain and inflammation in hemophilia.
Binder RA, Durocher J, Mielke CH. Treatment of Pain in Hemophilia: Effect of Drugs on Bleeding Time. Am J Dis Child. 1974;127(3):371–373. doi:10.1001/archpedi.1974.02110220069009
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