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March 1974

Weber-Christian Disease: With Nephrotic Syndrome

Author Affiliations

New Delhi
From the departments of pediatrics (Drs. Srivastava, Mayekar, and Anand) and pathology (Dr. Roy), All India Institute of Medical Sciences, New Delhi.

Am J Dis Child. 1974;127(3):420-421. doi:10.1001/archpedi.1974.02110220118018

Percutaneous renal biopsy in a child with nephrotic syndrome was followed by copious oozing of a clear, oily liquid from the skin puncture site. Subsequently, inflamed subcutaneous nodules appeared over the trunk and extremities suggesting Weber-Christian panniculitis. Extensive liquefication of fat occurred, especially over the abdomen, hips, and scrotum. Attacks of panniculitis subsided in nine months. The child received an eight-week therapy with cyclophosphamide and prednisone, and has remained free of proteinuria for one year.

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