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April 1974

Abnormal Electrical Activity of the Fetal Brain and Seizures of the Infant

Author Affiliations

Cleveland;; Margaret Steinbrecher, Rochester, NY
From the Department of Obstetrics and Gynecology, Cleveland Metropolitan General Hospital, Case Western Reserve University (Drs. Sokol and Rosen); and the Department of Pediatrics (Drs. Borgstedt and Lawrence) and the Fetal Brain Research Laboratory of the Department of Obstetrics and Gynecology (Ms. Steinbrecher), University of Rochester (NY) School of Medicine.

Am J Dis Child. 1974;127(4):477-483. doi:10.1001/archpedi.1974.02110230023003

With the development of an appropriate electrode, recording of the fetal electroencephalogram (FEEG) during labor has become a useful research technique. Four patients developed seizure activity in infancy. The FEEGs of these infants resemble the tracings obtained later in life. Abnormalities included persistent sharp-wave activity and prolonged voltage depression. In addition to the authors' knowledge, we have the first reported example of an FEEG with the appearance of periodic trace from a fetus who later developed hypsarrhythmia. The FEEG establishes abnormal electrical activity reflecting brain damage incurred prior to birth.

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