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May 1974

Infants Exposed in Utero to Antiepileptic Drugs: A Prospective Study

Author Affiliations

From the Department of Pediatrics and Institute for Lipid Research, Baylor College of Medicine, and the Newborn Research Unit, St. Luke's Episcopal Hospital, Houston.

Am J Dis Child. 1974;127(5):645-653. doi:10.1001/archpedi.1974.02110240031002

Twenty-eight newly born infants exposed in utero to various anticonvulsant drugs have been followed up from birth to 36 months of age, and their clinical status has been compared to that of 165 infants not exposed to these agents. A clustering of physical findings observed in the infants exposed to anticonvulsant agents makes these infants an identifiable population among neonates. Disfiguring or life-threatening malformations occurred more frequently in these infants, as did failure to thrive and Gesell developmental quotients of less than 90 at 21 months of age or greater. By the method of gas chromatography and mass spectrometry, commonly used anticonvulsant agents have been identified in maternal and neonatal urine and plasma.

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