The increasing sophistication of immunological tests for the diagnosis of congenital syphilis has been paralleled by a conspicuous lack of the placental examination as a means of morphologically confirming this diagnosis. Three recent cases of congenital syphilis showed a triad of placental changes: focal villitis, endovascular and perivascular proliferation in villous vessels, and relative immaturity of villi. Additionally, spirochetes were present. Placental examination has proved valuable in cases of suspected congenital syphilis.
Russell P, Altshuler G. Placental Abnormalities of Congenital Syphilis: A Neglected Aid to Diagnosis. Am J Dis Child. 1974;128(2):160–163. doi:10.1001/archpedi.1974.02110270034007
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