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August 1974

Rubella Vaccinees in a Public School System: A 4½-Year Follow-Up

Author Affiliations

Sally Trimble
From the Infectious Disease Division, Department of Internal Medicine (Drs. Schiff and Linnemann, Mrs. Shea, Mr. Rotte, and Ms. Trimble), and the Adolescent Medicine Division, Department of Pediatrics (Dr. Rauh), University of Cincinnati College of Medicine.

Am J Dis Child. 1974;128(2):180-183. doi:10.1001/archpedi.1974.02110270054011

Two hundred eighty-three Cendehill strain vaccinees and 268 HPV-77-DK-12 (DK) strain vaccinees in the Princeton School District of Cincinnati were followed up for 4½ years to determine persistence of vaccine-acquired serum antibody. The geometric mean titers (GMT) declined slightly in both groups. Seventeen (8.2%) of the Cendehill vaccinees and nine (4.3%) DK vaccinees experienced a substantial decline in serum antibody levels, while nine (4.3%) of the Cendehill vaccinees and four (6.1%) of the other vaccinees experienced a substantial increase. Clinical rubella was diagnosed in the school system but none of the vaccinees developed clinical evidence of reinfection. The general persistence of vaccine-induced antibody over a 4½-year period was encouraging.

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