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August 1974

Complications of Infectious Mononucleosis: A Fatal Case in a 2-Year-Old Child

Author Affiliations

From the departments of pediatrics, neurology, and pathology, Harvard Medical School, and the children's, neurology, and pathology services, Massachusetts General Hospital, Boston.

Am J Dis Child. 1974;128(2):239-243. doi:10.1001/archpedi.1974.02110270113023

Infectious mononucleosis has been usually considered a benign disease of adolescence and young adulthood. The present paper describes a fatal case of infectious mononucleosis in a 2-year-old boy, whose complications included Reye syndrome. After recovering from the Reye syndrome, he subsequently died from granulocytopenia and septicemia. Other complications included hepatitis, pneumonitis, gingivostomatitis, gastrointestinal bleeding, thrombocytopenia, and an ampicillin rash. The death and complications resulting from this usually benign entity have received little attention in the pediatric literature, and should be recalled by pediatricians confronted with a febrile child.

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