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October 1974

Hypercholesterolemia and Hypertriglyceridemia in Children: A Pediatric Approach to Primary Atherosclerosis Prevention

Author Affiliations

From the Department of Medicine (Drs. Glueck and Fallat) and the Fels Division of Pediatric Research (Drs. Glueck, Fallat, and Tsang), General Clinical Research Center, Cincinnati General Hospital; and the Children's Hospital Research Foundations (Dr. Tsang), Cincinnati.

Am J Dis Child. 1974;128(4):569-577. doi:10.1001/archpedi.1974.02110290139025

Atherosclerosis may have its genesis in childhood. Familial and acquired hypercholesterolemia and hypertriglyceridemia are easily described in children. Early diagnosis, family studies, and diet and drug therapy provide an opportunity for long-range primary amelioration of risk factors that contribute to atherosclerosis in adult life. Although there is currently no conclusive evidence that normalization of serum cholesterol and triglyceride levels in children will prevent accelerated development of atherosclerosis, prudent dietary and drug therapy appear to have considerable promise as a pediatric approach to prevention of atherosclerosis.