Aplasia cutis congenita is usually observed on the scalp as a small area devoid of skin. Its association with a number of congenital malformations is well documented.
Extensive aplasia cutis congenita, together with cerebral atrophy, was present in a girl with spastic paralysis and mental retardation. The cerebral atrophy is interpreted as the counterpart of the cutaneous lesion.
Ruiz-Maldonado R, Tamayo L. Aplasia Cutis Congenita, Spastic Paralysis, and Mental Retardation. Am J Dis Child. 1974;128(5):699–701. doi:10.1001/archpedi.1974.02110300109016