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February 1975

Absence of Intravascular Coagulation in the Hemolytic-Uremic Syndrome

Author Affiliations

From the Department of Pediatrics, Children's Hospital Research Foundation, Cincinnati. Dr. Kisker is now with the University of Iowa Hospitals, Iowa City.

Am J Dis Child. 1975;129(2):223-226. doi:10.1001/archpedi.1975.02120390055011

Four patients had clinical manifestations of the hemolytic-uremic syndrome. No evidence of active intravascular coagulation was found during the acute phase of the illness, using a sensitive assay to measure soluble circulating fibrin in the plasma of these patients, three of whom developed the clinical syndrome while hospitalized for gastroenteritis. These findings, coupled with the findings of others, suggest that either the episode of intravascular coagulation precedes the development of the clinical manifestations, or that platelet thrombosis is occurring in the absence of activation of plasma clotting factors. In any case, heparin anticoagulant therapy does not seem indicated.

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