Sir.—We are writing to compliment Joynt on his excellent review of an important and interesting event in medical history, the introduction of bromide as an antiepileptic agent, which appeared in the September issue of the Journal (128:362, 1974). However, his statement that bromide has not "been supplanted by treatments devised by modern methods of drug manufacture" is not supported by many current authors in the field of epilepsy. Because of the enthusiasm for the newer anticonvulsant drugs, bromide is not used extensively at present, and some investigators consider it to be only of historical interest. In fact, several writings on the treatment of epilepsy merely cite the past importance of bromides and then summarily dismiss them as ineffective and relatively toxic. It is thus readily comprehensible why so few younger physicians have little knowledge of the use of bromide as an anticonvulsant and have generally excluded this drug from
LIVINGSTON S, PAULI LL. The Use of Bromides for Epilepsy. Am J Dis Child. 1975;129(2):259. doi:10.1001/archpedi.1975.02120390083023
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.