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June 1975

Enteropathogenicity of Escherichia coli

Author Affiliations

Departments of Pediatrics and Microbiology State University of New York at Buffalo School of Medicine and Children's Hospital 219 Bryant St Buffalo, NY 14222

Am J Dis Child. 1975;129(6):666-667. doi:10.1001/archpedi.1975.02120430006003

Although infectious diarrheal disease of infants is one of the most common global disorders, the process of identification of the various pathogens and clarification of the pathogenesis of the disease has developed rather slowly. Certain enteric pathogens, such as salmonellae and shigellae, have been identified many decades ago. Far more difficult has been the elucidation of the role of seemingly "normal" inhabitants of the intestinal tract, notably Escherichia coli, first described by the pediatrician Escherich. It was half a century ago that the German pediatrician Adam1 suggested that special kinds of E coli (the Dyspepsiecoli) were responsible for diarrheal disease of infants. Viewed from the vantage point of today, the techniques available to him were quite inadequate and merely measured a few biochemical activities of the strains. Nonetheless, his concept proved to be correct. Some years later, serologic studies disclosed that certain strains of E coli recovered during epidemics

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