• Glucocorticoids cause growth retardation in children. We have studied the effect of these hormones on serum somatomedin (Sm) levels in seven children with nephrosis.
Intravenous administration of methyl-prednisolone sodium succinate, 2.2 mg/kg, causes a rapid fall in serum Sm activity. The activity remains suppressed during continuous therapy, but returns toward normal when medication is omitted during the course of alternate-day therapy. We conclude that one reason for growth retardation secondary to continuous glucocorticoid therapy is suppression of Sm generation. A direct effect of these hormones on the cartilage cell or induction of an Sm inhibitor cannot be excluded by the reported experiments.
(Am J Dis Child 129:1393-1396, 1975)
Elders MJ, Wingfield BS, McNatt ML, Clarke JS, Hughes ER. Glucocorticoid Therapy in Children: Effect on Somatomedin Secretion. Am J Dis Child. 1975;129(12):1393–1396. doi:10.1001/archpedi.1975.02120490011005
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