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February 1976

Congenital Graves Disease: Four Familial Cases With Long-Term Follow-Up and Perspective

Author Affiliations

From the Department of Pediatrics, University of Kentucky, Lexington.

Am J Dis Child. 1976;130(2):148-155. doi:10.1001/archpedi.1976.02120030038008

• Congenital Graves disease has been described as a transient disorder in which the mother has or has had hyperthyroidism. Experience with four affected children to ages 5 to 9 years and a review of published cases led us to conclude that long-acting thyroid stimulator (half-life, six days) is not the cause of the disease. This disease occurs in infants from families with a high incidence of Graves disease, and, in many, hyperthyroidism persists for months or years. The pathogenesis of Graves disease is unknown, and the simplistic maternal-to-fetal humoral theory is not a suitable explanation for congenital Graves disease. If Graves disease is considered in the larger perspective than the maternal-fetal unit, a pattern of inheritance is apparent, ie, an autosomal-dominant trait with a predilection for the female individual.

(Am J Dis Child 130:148-155, 1976)