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April 1976

Fatal Disseminated BCG Infection: An Investigation of the Immunodeficiency

Author Affiliations

From the departments of pediatrics "B" (Drs Passwell, Frank, Cohen, and Ziprkowski) and pathology (Dr Katz), the Chaim Sheba Medical Center, the Department of Pediatrics (Dr Spirer), Hadassah Municipal Hospital, and the Tel Aviv University Sackler School of Medicine, Israel.

Am J Dis Child. 1976;130(4):433-436. doi:10.1001/archpedi.1976.02120050091018

• A 2-year-old boy had a fatal disseminated BCG infection. Immunologic assessment showed a normal humoral response and normal numbers of E rosettes, normal thymus weight and histological features, but an abnormal response of lymphocytes in vitro and negative skin tests. Histological examination showed the presence of Gram-negative acid-fast bacilli within the macrophages. The possible mechanisms of immunodeficiency in this patient are discussed.

(Am J Dis Child 130:433-436, 1976)

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