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June 1976

Chemotherapy of Childhood Medulloblastoma

Author Affiliations

From the Edward Mallinckrodt Department of Pediatrics, Washington University, and the Division of Pediatric Hematology and Oncology, St Louis Children's Hospital, St Louis. Dr Crist is currently with the Department of Pediatrics and the Division of Hematology and Oncology, Children's Hospital, University of Alabama School of Medicine, Birmingham. Dr Ragab is currently with the Department of Pediatrics, Emory University School of Medicine, Atlanta.

Am J Dis Child. 1976;130(6):639-642. doi:10.1001/archpedi.1976.02120070065013

• A number of chemotherapeutic agents have been shown to have antitumor activity against childhood medulloblastoma. Ten-year survival with optimal surgery and radiation therapy ranges from 5% to 25%. Carefully controlled clinical trials utilizing a combination of surgery, radiation therapy, and chemotherapy should be employed in the early stages of the disease in an attempt to define which drugs are most effective, and to improve the survival rate.

(Am J Dis Child 130:639-642, 1976)

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