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August 1976

Neurologic Infections in Children

Author Affiliations

Department of Pediatrics University of California at Los Angeles School of Medicine Center for Health Sciences Los Angeles, CA 90024

Am J Dis Child. 1976;130(8):904-905. doi:10.1001/archpedi.1976.02120090114030

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This book contains an extensive bibliography, is well illustrated, and it is apparent that the authors put much effort into it. However, I must say at the outset that it contains many minor and several major errors. In addition to clear-cut errors, there are also numerous instances of over- or under-emphasis of available data, which could lead the unwary reader to diagnostic and therapeutic mistakes in the clinical situation.

Chapter 1 is entitled "Bacterial Meningitis: General Concepts and Management." In this chapter, antibiotic data are often incomplete, wrong, and unrelated. For example, the dose of ampicillin sodium for the premature infant (50 mg/kg/day) is insufficient. In Table 1-5, the ampicillin dosage interval is stated as four to six hours. It is important to emphasize that all reliable published studies on the use of ampicillin in meningitis employed four-hour intervals. The authors state, "In order to establish adequate blood levels rapidly

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